Asymptomatic dengue infection rate: A systematic literature review

ObjectivesDengue infection is spreading worldwide. The clinical spectrum broad and includes asymptomatic infections. This review provides an overview of the different proportions infections described in epidemiological studies according to definitions, study designs, detection methods.MethodsMedline Embase databases were searched without restriction date or language. Studies included if they reported data on incidence prevalence dengue summarized classified definitions term 'asymptomatic'.ResultsA total 74 included. mean proportion among dengue-infected persons was 54% 50 studies. detected healthy 0.2% 24 ‘asymptomatic’ has been used refer ‘clinically undetectable infection’, but also ‘undiagnosed infection’ ‘mild infection’. Only 8% clinically laboratory-confirmed infections.ConclusionThe varied greatly. proving very few, provided consistent results low These challenge assumption that majority cases are asymptomatic.